EPIGENETICS OF CARCINOGENESIS

Nickel carcinogenesis, mutation, epigenetics, or selection.

ofcells to carcinogenic nickel compounds induces many genes that are commonly expressed in cancer cells but not in normal cells. Nickel compounds have been well established as human carcinogens. Investigations into the molecular mechanisms of nickel car-cinogenesis have revealed that not all nickel compounds are equally carcinogenic: certain water-insoluble nickel compounds exhibit potent carci...

Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics.

DNA mismatch repair (MMR) deficiency results in a strong mutator phenotype and high-frequency microsatellite instability (MSI-H), which are the hallmarks of tumors arising within Lynch syndrome. MSI-H is characterized by length alterations within simple repeated sequences, microsatellites. Lynch syndrome is primarily due to germline mutations in one of the DNA MMR genes; mainly hMLH1 or hMSH2 a...

Epigenetics in metal carcinogenesis: nickel, arsenic, chromium and cadmium.

Although carcinogenic metals have been known to disrupt a wide range of cellular processes the precise mechanism by which these exert their carcinogenic effects is not known. Over the last decade or two, studies in the field of metal carcinogenesis suggest that epigenetic mechanisms may play a role in metal-induced carcinogenesis. In this review we summarize the evidence demonstrating that expo...

The Prospects of Epigenetics in Neuroscience

First European Cancer and Environment Research Institute Workshop ENVIRONMENTAL CARCINOGENESIS: A FOCUS ON EPIGENETICS